Abstract | OBJECTIVE: The purpose of this study was to investigate whether cell-free placental mRNA levels have the potential to predict a placenta previa resulting in hysterectomy. METHODS: Twenty-eight singleton pregnant women with placenta previa were classified into the following four groups: 16 women with placenta located at a posterior part of the uterine wall (Group A); 4 each with placenta located at the anterior wall without (Group B) or with (Group C) previous cesarean section; and the other 4 with a history of previous cesarean section and who had the placenta located at an anterior part of uterine wall and underwent a cesarean hysterectomy (Group D). The maternal plasma concentrations of the cell-free placental lactogen (PL) mRNA measured by real-time reverse-transcription polymerase chain reaction (PCR) were converted into multiples of the median (MoM). RESULTS: The MoM (range) values of cell-free PL mRNA in the control group and Groups A to D were 1.00 (0.39-2.35), 2.04 (0.91-3.93), 2.58 (1.90-3.90), 3.50 (1.20-4.30), and 6.28 (5.24-7.63), respectively. The concentration of cell-free PL mRNA was significantly higher in Group D than in Group A, B, or C (Mann-Whitney's U-test, P < 0.05). CONCLUSION:
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Authors | Kiyonori Miura, Shoko Miura, Kentaro Yamasaki, Atsushi Yoshida, Koh-Ichiro Yoshiura, Daisuke Nakayama, Norio Niikawa, Hideaki Masuzaki |
Journal | Prenatal diagnosis
(Prenat Diagn)
Vol. 28
Issue 9
Pg. 805-9
(Sep 2008)
ISSN: 0197-3851 [Print] England |
PMID | 18646248
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2008 John Wiley & Sons, Ltd. |
Chemical References |
- Biomarkers
- RNA, Messenger
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Topics |
- Biomarkers
(blood)
- Case-Control Studies
- Cohort Studies
- Female
- Humans
- Hysterectomy
- Pilot Projects
- Placenta Accreta
(blood, diagnostic imaging, surgery)
- Placenta Previa
(blood, diagnostic imaging)
- Predictive Value of Tests
- Pregnancy
- RNA, Messenger
(blood)
- Ultrasonography, Prenatal
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