Abstract | HYPOTHESIS: DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: Five hundred seventy-six consecutive patients with HPT. INTERVENTION: MAIN OUTCOME MEASURES: Overall incidence of elevated PTH levels (measurements of >or= 70 pg/mL at any time during follow-up) and recurrent HPT ( hypercalcemia and elevated PTH levels more than 6 months after parathyroidectomy). RESULTS: Of the 505 patients who underwent successful parathyroidectomy in this series and were followed up for more than 6 months, 337 (66.7%) consistently had PTH levels within the reference range, and 168 (33.3%) had elevated PTH levels. Of the 168 patients with elevated PTH levels, only 8 (4.8%) developed recurrent disease. The earliest recurrence occurred 2 years postoperatively. Factors associated with elevated PTH levels included advanced age, higher preoperative PTH levels, and mild postoperative renal insufficiency. CONCLUSION: Although one-third of the patients had elevated PTH levels after successful parathyroidectomy, most of these patients with elevated PTH levels (95%) will achieve long-term eucalcemia.
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Authors | Carmen C Solorzano, William Mendez, John I Lew, Steven E Rodgers, Raquel Montano, Denise M Carneiro-Pla, George L Irvin 3rd |
Journal | Archives of surgery (Chicago, Ill. : 1960)
(Arch Surg)
Vol. 143
Issue 7
Pg. 659-63; discussion 663
(Jul 2008)
ISSN: 1538-3644 [Electronic] United States |
PMID | 18645108
(Publication Type: Journal Article)
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Chemical References |
- Parathyroid Hormone
- Calcium
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Calcium
(blood)
- Female
- Humans
- Hyperparathyroidism
(surgery)
- Male
- Middle Aged
- Parathyroid Hormone
(blood)
- Parathyroidectomy
- Postoperative Period
- Recurrence
- Retrospective Studies
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