Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus.

Abstract

The effects of tetrapeptide pancragen (Lys-Glu-Asp-Trp-NH2) on blood glucose level and permeability and adhesion of mesenteric capillaries were studied in Wistar rats with experimental streptozotocin-induced diabetes mellitus. Oral pancragen produced a pronounced hypoglycemic effect during treatment. Intramuscular pancragen normalized the adhesion of mesenteric capillary endothelium, but did not modify capillary permeability. The results indicate homeostatic and endothelioprotective effects of pancragen during the early period of diabetes mellitus.

• Authors: V Kh Khavinson, N A Gavrisheva, V V Malinin, S G Chefu, E L Trofimov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 144 Issue 4 Pg. 559-62 (Oct 2007) ISSN: 0007-4888 [Print] United States
• PMID: 18642713 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Oligopeptides
• lysyl-glutamyl-aspartyl-tryptophan
• lysyl-glutamyl-aspartyl-tryptophanamide
• Streptozocin

Topics

• Administration, Oral
• Animals
• Blood Glucose (analysis)
• Capillary Permeability (drug effects)
• Cell Adhesion (drug effects)
• Diabetes Mellitus, Experimental (blood, chemically induced, drug therapy)
• Injections, Intramuscular
• Male
• Mesentery (blood supply)
• Oligopeptides (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Streptozocin