Abstract | BACKGROUND: METHODS: In this randomized, prospective, controlled study, 17 New Zealand white rabbits underwent bilateral corneal de-epithelialization procedures using 20% alcohol contained within a 6 mm trephine. Postoperatively, eyes were randomly assigned to receive either gatifloxacin 0.3%, moxifloxacin 0.5%, or balanced salt solution (BSS) four times daily. Each 6 hours during the first 2 days, and every 12 hours thereafter slit-lamp measurements and corneal photography were performed, enabling de-epithelialized surface areas to be calculated via EPCO 2000 computer analysis. RESULTS:
Gatifloxacin (n = 12) and moxifloxacin (n = 13) treated eyes had a statistically significant (p = 0.036) delay in epithelial healing relative to controls (BSS, n = 8). Healing rates of gatifloxacin and moxifloxacin treated eyes were not significantly different (p = 0.545). CONCLUSIONS: We found no significant difference in re-epithelialization rates following topical application of gatifloxacin 0.3% and moxifloxacin 0.5%. Both antibiotic solutions delayed healing compared to BSS. Our analysis suggests that there was no apparent added epithelial toxicity due to the presence of BAK in the gatifloxacin preparation.
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Authors | Majid Moshirfar, Jesse Chew, Liliana Werner, Jay J Meyer, Brian Hunter, Scott Stevens, Mike Jensen, Guy Kleinmann, Nick Mamalis |
Journal | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
(Graefes Arch Clin Exp Ophthalmol)
Vol. 246
Issue 10
Pg. 1455-61
(Oct 2008)
ISSN: 0721-832X [Print] Germany |
PMID | 18642018
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Aza Compounds
- Benzalkonium Compounds
- Fluoroquinolones
- Ophthalmic Solutions
- Preservatives, Pharmaceutical
- Quinolines
- Ethanol
- Gatifloxacin
- Moxifloxacin
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Topics |
- Administration, Topical
- Animals
- Anti-Infective Agents
(administration & dosage, pharmacology)
- Aza Compounds
(administration & dosage, pharmacology)
- Benzalkonium Compounds
(administration & dosage, pharmacology)
- Corneal Diseases
(chemically induced, diagnosis, drug therapy)
- Disease Models, Animal
- Epithelium, Corneal
(drug effects, pathology)
- Ethanol
- Female
- Fluoroquinolones
(administration & dosage, pharmacology)
- Gatifloxacin
- Image Processing, Computer-Assisted
- Male
- Moxifloxacin
- Ophthalmic Solutions
(administration & dosage, pharmacology)
- Preservatives, Pharmaceutical
(administration & dosage, pharmacology)
- Prospective Studies
- Quinolines
(administration & dosage, pharmacology)
- Rabbits
- Wound Healing
(drug effects)
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