Abstract |
The present study evaluates the effects of agmatine on histopathological damage following traumatic injury using a clinically relevant model of diffuse brain injury. A total of 27 male Sprague-Dawley rats weighing 200-225 g were anaesthetised and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two main groups: one was treated with agmatine and the other with saline for up to 4 days immediately after head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the axonal, neuronal and vascular changes associated with diffuse brain injury. There were no significant differences between the groups at 1 day or 3 days after trauma, but evaluation after 8 days revealed a significant improvement in the group treated with agmatine. Our data indicate that agmatine has a beneficial effect in diffuse brain injury and should be trialled for therapeutic use in the management of this condition.
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Authors | Goksin Sengul, Erhan Takci, Umit Ali Malcok, Ali Akar, Fazli Erdogan, Hakan Hadi Kadioglu, Ismail Hakki Aydin |
Journal | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
(J Clin Neurosci)
Vol. 15
Issue 10
Pg. 1125-9
(Oct 2008)
ISSN: 0967-5868 [Print] Scotland |
PMID | 18640839
(Publication Type: Journal Article)
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Chemical References |
- Neuroprotective Agents
- Neurotransmitter Agents
- Agmatine
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Topics |
- Agmatine
(pharmacology)
- Animals
- Axons
(drug effects, pathology)
- Brain
(blood supply, drug effects, pathology)
- Brain Injuries
(drug therapy, pathology)
- Cerebrovascular Circulation
(drug effects)
- Disease Models, Animal
- Head Injuries, Closed
(complications)
- Male
- Neurons
(drug effects, pathology)
- Neuroprotective Agents
(pharmacology)
- Neurotransmitter Agents
(pharmacology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Statistics, Nonparametric
- Time Factors
- Treatment Outcome
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