Abstract | BACKGROUND: METHODS: We did a large, standardised case-control study of acute myocardial infarction in 12,461 cases and 14,637 age-matched (plus or minus 5 years) and sex-matched controls in 52 countries. Non-fasting blood samples were available from 9345 cases and 12,120 controls. Concentrations of plasma lipids, lipoproteins, and apolipoproteins were measured, and cholesterol and apolipoprotein ratios were calculated. Odds ratios (OR) and 95% CI, and population-attributable risks (PARs) were calculated for each measure overall and for each ethnic group by comparison of the top four quintiles with the lowest quintile. FINDINGS: INTERPRETATION: The non-fasting ApoB/ApoA1 ratio was superior to any of the cholesterol ratios for estimation of the risk of acute myocardial infarction in all ethnic groups, in both sexes, and at all ages, and it should be introduced into worldwide clinical practice.
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Authors | Matthew J McQueen, Steven Hawken, Xingyu Wang, Stephanie Ounpuu, Allan Sniderman, Jeffrey Probstfield, Krisela Steyn, John E Sanderson, Mohammad Hasani, Emilia Volkova, Khawar Kazmi, Salim Yusuf, INTERHEART study investigators |
Journal | Lancet (London, England)
(Lancet)
Vol. 372
Issue 9634
Pg. 224-33
(Jul 19 2008)
ISSN: 1474-547X [Electronic] England |
PMID | 18640459
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins
- Biomarkers
- Lipoproteins
- Cholesterol
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Topics |
- Adult
- Aged
- Apolipoproteins
(blood)
- Biomarkers
- Case-Control Studies
- Cholesterol
(blood)
- Ethnicity
- Female
- Humans
- Lipoproteins
(blood)
- Male
- Middle Aged
- Myocardial Infarction
(blood)
- ROC Curve
- Risk Factors
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