Sialyl alpha(2-->3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers.

Abstract

An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl alpha(2-->3) lactose (Neu5Acalpha(2-->3)Galbeta(1-->4)Glcbeta1-->) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure-activity relationship according to the carbosilane scaffolds.

• Authors: Hiroyuki Oka, Tomotsune Onaga, Tetsuo Koyama, Chao-Tan Guo, Yasuo Suzuki, Yasuaki Esumi, Ken Hatano, Daiyo Terunuma, Koji Matsuoka
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 15 Pg. 4405-8 (Aug 01 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18639456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Dendrimers
• Hemagglutinin Glycoproteins, Influenza Virus
• Silanes
• Lactose

Topics

• Antiviral Agents (chemical synthesis, chemistry, pharmacology)
• Combinatorial Chemistry Techniques
• Dendrimers (chemical synthesis, chemistry, pharmacology)
• Drug Design
• Hemagglutination Tests
• Hemagglutinin Glycoproteins, Influenza Virus (metabolism)
• Humans
• Influenza A Virus, H1N1 Subtype (drug effects)
• Influenza A Virus, H3N2 Subtype (drug effects)
• Lactose (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
• Molecular Structure
• Parainfluenza Virus 1, Human (drug effects)
• Silanes (chemical synthesis, chemistry, pharmacology)
• Structure-Activity Relationship