Successful psychotropic management of drug related psychosis in Parkinson's disease.

Abstract

This study reports on the clinical effectiveness of the combined use of conventional major tranquillisers and augmented levodopa dosage for the management of paranoia, hallucinations and confusion in patients with Parkinson's disease (PD). The medical records of patients admitted with PD and target symptoms were retrospectively reviewed. A total of 52 patients were treated over the 3 year period. Approximately 70% demonstrated an improvement in psychotic symptoms, but only 54% could also maintain mobility. Side-effects occurred in 37% of patients and consisted of decreased mobility, excessive sedation and excessive salivation. The drop out rate on follow-up was 47% so that at the end of the 3 year period 23 patients still remained on the major tranquilliser from 44 patients who were discharged on a major tranquilliser. The effectiveness of this approach is similar to that published for atypical major tranquillisers; however, the tranquillisers used in this study do not carry the risks of serious side effects or high cost.

• Authors: R Iansek, H Feniger, V Costello, U Smee, I Presnell
• Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 6 Issue 6 Pg. 488-91 (Nov 1999) ISSN: 0967-5868 [Print] Scotland
• PMID: 18639186 (Publication Type: Journal Article)