Abstract | BACKGROUND/AIMS:
Growth hormone (GH) is necessary for optimal reproductive efficiency and its secretion is influenced by sex steroids. This study was designed to determine whether kisspeptin-10 (Kp10) could stimulate GH and if gonadal steroids enhance the GH response to Kp10 in cows. METHODS AND RESULTS: CONCLUSIONS: These data suggest that reproductive steroids enhance the sensitivity of the somatotropic axis to physiologically relevant doses of Kp10, and support the possibility that Kp10 is an integrator of luteinizing hormone and GH release.
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Authors | Brian K Whitlock, Joseph A Daniel, Robyn R Wilborn, Soren P Rodning, Herris S Maxwell, Barbara P Steele, James L Sartin |
Journal | Neuroendocrinology
(Neuroendocrinology)
Vol. 88
Issue 3
Pg. 212-5
( 2008)
ISSN: 1423-0194 [Electronic] Switzerland |
PMID | 18635924
(Publication Type: Comparative Study, Journal Article)
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Copyright | 2008 S. Karger AG, Basel. |
Chemical References |
- Drug Combinations
- KISS1 protein, human
- Kisspeptins
- Oligopeptides
- Progesterone
- Estradiol
- Luteinizing Hormone
- Growth Hormone
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Topics |
- Animals
- Cattle
- Dose-Response Relationship, Drug
- Drug Combinations
- Drug Interactions
- Estradiol
(pharmacology)
- Female
- Growth Hormone
(metabolism)
- Injections, Intravenous
- Kisspeptins
- Luteinizing Hormone
(metabolism)
- Oligopeptides
(administration & dosage, pharmacology)
- Ovariectomy
- Progesterone
(pharmacology)
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