Supplementing vitamin B6 to a low vitamin B6 diet exaggerates UVB-induced skin tumorigenesis in DMBA-treated hairless mice.

Abstract

7,12-Dimethylbenz[a]anthracene (DMBA)-treated hairless mice exposed to UVB radiation were used to examine the effect of graded levels of vitamin B(6) [1, 7 or 35 mg pyridoxine (PN) HCl/kg] on skin tumorigenesis for 18 wk. Compared to the 1 mg PN HCl/kg diet, the 35 mg PN HCl/kg diet significantly elevated the incidence and multiplicity of skin tumors, while there was no difference in skin tumorigenesis between the 7 and 35 mg PN HCl/kg diets. Skin levels of oxidative stress markers (lipid peroxides and protein carbonyls) were unaffected by dietary treatment. Compared to the 1 mg PN HCl/kg diet, the 7 and 35 mg PN HCl/kg diets significantly elevated serum pyridoxal 5'-phosphate (PLP) without affecting the skin level of PLP. The results suggest that dietary supplemental vitamin B(6) exaggerates UVB-induced skin tumorigenesis in hairless mice without affecting oxidative stress in the skin.

• Authors: Tao Lu, Yonghui Xu, Elise Saiz Monttinen, Norihisa Kato
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 54 Issue 3 Pg. 262-5 (Jun 2008) ISSN: 0301-4800 [Print] Japan
• PMID: 18635915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Carcinogens
• Thiobarbituric Acid Reactive Substances
• Vitamin B Complex
• 9,10-Dimethyl-1,2-benzanthracene
• Pyridoxal Phosphate
• Vitamin B 6
• Pyridoxine

Topics

• 9,10-Dimethyl-1,2-benzanthracene (administration & dosage)
• Animals
• Biomarkers (blood, metabolism)
• Carcinogens (administration & dosage)
• Diet (adverse effects, methods)
• Dietary Supplements (adverse effects)
• Dose-Response Relationship, Drug
• Female
• Mice
• Mice, Hairless
• Oxidative Stress (drug effects, radiation effects)
• Pyridoxal Phosphate (blood)
• Pyridoxine (metabolism, pharmacology)
• Skin (drug effects, metabolism, radiation effects)
• Skin Neoplasms (blood, metabolism)
• Thiobarbituric Acid Reactive Substances (metabolism)
• Ultraviolet Rays (adverse effects)
• Vitamin B 6 (adverse effects, metabolism, pharmacology)
• Vitamin B 6 Deficiency (drug therapy, metabolism)
• Vitamin B Complex (adverse effects, metabolism, pharmacology)