HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Modification of cardiometabolic risk through cannabinoid type-1 receptor antagonism.

Abstract
Large-scale epidemiological studies show that hypertension, diabetes, and dyslipidaemia are highly prevalent among obese individuals. Regrettably, preventive efforts have failed to abolish the increasing prevalence of obesity worldwide. The endocannabinoid system is implicated in the regulation of appetite, food intake, lipids, and glucose metabolism. Rimonabant is the first type-1 endocannabinoid receptor blocker that has been shown to improve the serum lipid profile, insulin and glucose levels, and blood pressure. In particular, the RIO (rimonabant in obesity) studies documented the beneficial metabolic effects of rimonabant. These favorable metabolic effects exceed by about 50% those anticipated by weight reduction, possibly due to modulation of the endocannabinoid system in peripheral tissues. The beneficial effects, however, seem to come at the cost of an increased risk of psychiatric disorders. However, given the efficacy of this treatment and the magnitude of the obesity problem, rimonabant may prove to be a valuable adjunct in targeting obesity-related cardiovascular risk factors.
AuthorsGeorge K Andrikopoulos, Stylianos Tzeis
JournalAngiology (Angiology) 2008 Apr-May Vol. 59 Issue 2 Suppl Pg. 44S-8S ISSN: 1940-1574 [Electronic] United States
PMID18635590 (Publication Type: Journal Article, Review)
Chemical References
  • Piperidines
  • Pyrazoles
  • Receptor, Cannabinoid, CB2
  • rimonabant
Topics
  • Cardiovascular Diseases (etiology, metabolism, prevention & control)
  • Humans
  • Obesity (complications, drug therapy, metabolism)
  • Piperidines (therapeutic use)
  • Pyrazoles (therapeutic use)
  • Receptor, Cannabinoid, CB2 (antagonists & inhibitors)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: