[A case of peritoneal dissemination caused by recurrent hilar cholangiocarcinoma treated with intraperitoneal infusion of cisplatin (CDDP) and systemic chemotherapy].

Abstract

Six years and 9 months ago, a 72-year-old man underwent left hepatectomy for a hilar cholangiocarcinoma(T2N0M0: Stage II A). At 3 years and 2 months after surgery, he was admitted for rectal tumor and reoperation. From surgery, it was diagnosed as peritoneal metastases of the cholangiocarcinoma, and an intraperitoneal infusion port was placed. He was treated with gemcitabine administered iv at day 1 and CDDP ip at day 8 every 3 or 4 weeks for 2 years. Then, gemcitabine was changed to docetaxel because of elevation of CA19-9. Both docetaxel iv and CDDP ip were administered for one and half years. For 3 years and 4 months, 12.2 g of CDDP, 28.0 g of gemcitabine and 920 mg of docetaxel were administered. As serum CA19-9 elevated again, he has been treated with S-1 and docetaxel ip for 3 months. This case indicates that intraperitoneal application of CDDP with systematic chemotherapy was effective for carcinomatous peritonitis without serious side effects.

• Authors: Yuzo Fujii, Kunihiko Nakazawa, Toshihiko Yoneto, Yutaka Shuzui
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 7 Pg. 1225-8 (Jul 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18633269 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Biomarkers, Tumor (blood)
• Cholangiocarcinoma (diagnostic imaging, drug therapy, pathology, surgery)
• Cisplatin (administration & dosage, therapeutic use)
• Humans
• Infusions, Parenteral
• Liver Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
• Male
• Neoplasm Staging
• Peritoneal Neoplasms (blood, diagnostic imaging, drug therapy, secondary)
• Tomography, X-Ray Computed