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[A patient in whom oral UFT/Leucovorin therapy proved markedly effective for lung metastasis after surgery for colon cancer].

Abstract
A 78-year-old male with sigmoid colon cancer underwent sigmoidectomy. The lesion was se, p1(+), n1, and Stage IV. Oral UFT therapy was performed, but was replaced with oral S-1 therapy 1 year and 6 months after surgery. Three months later, lung metastases 2.0 x 1.5 cm and 0.6 x 0.6 cm were found by chest CT in right S10a and S5b, respectively. Since the patient did not wish surgery, the treatment was changed to oral UFT/Leucovorin(LV)therapy(UFT 300 mg/ LV 75 mg, 4-week administration and 1-week no-administration periods). After 2 courses, chest CT showed disappearance of both lung metastases, indicating complete remission. Oral UFT/LV therapy is convenient because of the oral route. Adverse reactions are few, and the therapeutic effect has been reported to be comparable to that of intravenous 5-FU/LV therapy. Also, in this patient, no adverse reaction was noted, and complete remission was maintained until the patient died of another disease 31 months after the beginning of oral UFT/LV therapy.
AuthorsMikio Okamura, You Kamiizumi, Norio Kawamura, Ryoji Yokoyama, Koji Itoh, Kenji Abe, Yasuaki Nakajima
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 7 Pg. 1205-7 (Jul 2008) ISSN: 0385-0684 [Print] Japan
PMID18633264 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Tegafur
  • Uracil
  • Leucovorin
Topics
  • Administration, Oral
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Colonic Neoplasms (diagnostic imaging, drug therapy, pathology, surgery)
  • Humans
  • Leucovorin (administration & dosage, therapeutic use)
  • Lung Neoplasms (diagnostic imaging, drug therapy, secondary)
  • Male
  • Radiography
  • Tegafur (administration & dosage, therapeutic use)
  • Uracil (administration & dosage, therapeutic use)

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