| Abstract | A 46-year-old female was admitted to Kagoshima University Hospital with a complaint of epigastralgia and dysphasia. Gastrointestinal scopy revealed advanced gastric cancer in the upper third of the stomach. Pathological diagnosis of the biopsy specimen was moderately-differentiated adenocarcinoma. Abdominal CT suggested multiple liver metastases, so a combination of biweekly paclitaxel(PTX)and S-1 was started. After five courses of this regimen, the liver metastases and primary tumor were remarkably regressed. PTX was discontinued because of a grade 3 adverse effect of numbness. Nevertheless S-1 monotherapy for liver metastases resulted in a complete response. She has been well without tumor re-growth for 4 years. The combination of PTX and S-1 may be an effective regimen for gastric cancer with liver metastases. |
| Authors | Sumiya Ishigami, Takahiro Hamada, Akihiro Nakajo, Yoshikazu Uenosono, Takaaki Arigami, Tetsuro Setoyama, Yasuto Uchikado, Masataka Matsumoto, Shoji Natsugoe, Takashi Aikou
(Affiliation: Dept. of Surgical Oncology, Digestive Surgery Kagoshima University School of Medicine.)
|
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 35
Issue 7
Pg. 1197-9
(Jul 2008)
ISSN: 0385-0684 Japan |
| PMID | 18633262
(Publication Type: Case Reports, English Abstract, Journal Article)
|
| Chemical References |
- Drug Combinations
- S 1 (combination)
- Tegafur
- Paclitaxel
- Oxonic Acid
|
| Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Drug Combinations
- Female
- Gastroscopy
- Humans
- Liver Neoplasms
(radiography, secondary)
- Middle Aged
- Neoplasm Staging
- Oxonic Acid
(therapeutic use)
- Paclitaxel
(therapeutic use)
- Stomach Neoplasms
(drug therapy, pathology, radiography)
- Tegafur
(therapeutic use)
- Tomography, X-Ray Computed
|
