Antiemetic prophylaxis for postdischarge nausea and vomiting and impact on functional quality of living during recovery in patients with high emetic risks: a prospective, randomized, double-blind comparison of two prophylactic antiemetic regimens.

We compared two antiemetic prophylaxis regimens, their efficacy for preventing postdischarge nausea and vomiting, and their impact on quality of living, during recovery.
Sixty-four women undergoing outpatient gynecological surgery and at high risk for emesis were randomized into one of two groups. The study group received intraoperative IV dexamethasone 8 mg and ondansetron 4 mg, followed with an 8 mg oral disintegrating ondansetron tablet, to be taken on discharge and in the morning of postoperative days 1 and 2. The control group received only the IV ondansetron 4 mg intraoperatively. The incidence and severity of emetic symptoms and pain were assessed while patients were in the recovery room and via telephone and patient diary for 5 days after discharge. A modified functional living index of emesis was used to assess the impact on quality of living during recovery.
Sixty patients, 30 in each group, completed the study. The incidences for postdischarge nausea were 57% and 20%, and for postdischarge vomiting 20% and 3% in the control and study groups, respectively, for the period between the 8th and 120th hours postanesthesia (P < 0.05). Thirty-three percent of the study and 60% of the control group reported that emetic symptoms negatively affected their quality of living (P < 0.05).
When compared with a single dose of intraoperative IV ondansetron prophylaxis, our study regimen of additional intraoperative dexamethasone and once a day ondansetron significantly reduced the incidence of postdischarge nausea and vomiting and its negative impact on quality of living during the first 5 days of recovery.
AuthorsPeter H Pan, Sherman C Lee, Lynne C Harris
JournalAnesthesia and analgesia (Anesth Analg) Vol. 107 Issue 2 Pg. 429-38 (Aug 2008) ISSN: 1526-7598 [Electronic] United States
PMID18633020 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiemetics
  • Ondansetron
  • Dexamethasone
  • Administration, Oral
  • Adult
  • Ambulatory Surgical Procedures
  • Antiemetics (administration & dosage)
  • Dexamethasone (administration & dosage)
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Gynecologic Surgical Procedures
  • Humans
  • Infusions, Intravenous
  • Ondansetron (administration & dosage)
  • Pain, Postoperative (drug therapy)
  • Patient Discharge
  • Postoperative Nausea and Vomiting (prevention & control)
  • Quality of Life

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