Abstract | BACKGROUND AND OBJECTIVES: Since the first description of pathology of the kidney in Waldenström disease in 1970, there have been few reports on kidney complications of IgM-secreting monoclonal proliferations. Here, we aimed to revisit the spectrum of renal lesions occurring in patients with a serum monoclonal IgM. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Fourteen patients with a circulating monoclonal IgM and a kidney disease related to B cell proliferation were identified retrospectively. Demographic, clinical, and laboratory data were assessed for each patient at the time of kidney biopsy. RESULTS: CONCLUSIONS: Although renal complications of IgM proliferations are rare, a wide spectrum of kidney lesions is observed, without correlation with the type of hematologic disorder.
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Authors | Vincent Audard, Benoit Georges, Philippe Vanhille, Cécile Toly, Benjamin Deroure, Fadi Fakhouri, René Cuvelier, Xavier Belenfant, Brigitte Surin, Pierre Aucouturier, Béatrice Mougenot, Pierre Ronco |
Journal | Clinical journal of the American Society of Nephrology : CJASN
(Clin J Am Soc Nephrol)
Vol. 3
Issue 5
Pg. 1339-49
(Sep 2008)
ISSN: 1555-905X [Electronic] United States |
PMID | 18632851
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Immunoglobulin M
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Topics |
- Aged
- Amyloidosis
(immunology)
- Antibodies, Monoclonal
(analysis)
- B-Lymphocytes
(immunology, pathology)
- Cell Proliferation
- Female
- Glomerulonephritis, Membranoproliferative
(immunology)
- Humans
- Immunoglobulin M
(analysis)
- Kidney Diseases
(drug therapy, immunology, pathology, physiopathology)
- Lymphoma, B-Cell
(immunology)
- Lymphoma, B-Cell, Marginal Zone
(immunology)
- Lymphoproliferative Disorders
(complications, drug therapy, immunology, pathology)
- Male
- Middle Aged
- Multiple Myeloma
(immunology)
- Nephrotic Syndrome
(immunology)
- Retrospective Studies
- Treatment Outcome
- Waldenstrom Macroglobulinemia
(immunology)
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