[A comparative study on effect of bacterial load in diabetic foot ulcers dealing with iodophor and rivanol respectively].

Abstract

OBJECTIVE:

To investigate the change of bacterial load applied with iodophors and rivanol of diabetic foot ulcers (DFUs), furthermore to evaluate the effect of both in removing superficial microbes of DFUs.

METHODS:

From March 2006 to March 2007, 30 patients were randomly divided into control group (group A, n = 10), iodophor group (group B, n = 10) and rivanol group (group C, n = 10). There were 18 males and 12 females with an average age of 59.8 years (range 46-78 years). The wound size ranged from 3 cm x 2 cm to 15 cm x 10 cm. The disease course was 6 weeks to 6 months (mean 2.1 months). Each wound was debrided and irrigated before process, then drug was compressed on the wound for 5 minutes, and irrigated again. The samples gained for three times, before, immediately and 24 hours after the process. Each sample was diluted before cultivation, the bacteria of wound were counted and compared among 3 groups.

RESULTS:

The cultures of specimens showed that the load decreased in every group, each cultured colony of specimen grew well, and there were no significant differences between 3 groups immediately after procedure (P > 0.05). There were significant differences between group B and groups A, C (P < 0.05), but there were no significant difference between group A and group C 24 hours after treatment (P > 0.05).

CONCLUSION:

Both iodophors and rivanol could remove the bacteria on the surface of wound. Topical germicide could reduced bacterial load in the wound of diabetic foot, the role of sterilizing and bacteriostasis of iodophors were better than that of rivanol.

• Authors: Wenzhong Chen, Kai Xu, Hui Zhang, Yan Shang, Ping Hao
• Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery (Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi) Vol. 22 Issue 5 Pg. 567-70 (May 2008) ISSN: 1002-1892 [Print] China
• PMID: 18630437 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Iodophors
• Ethacridine

Topics

• Aged
• Aged, 80 and over
• Anti-Infective Agents, Local (therapeutic use)
• Colony Count, Microbial
• Diabetic Foot (drug therapy, microbiology)
• Ethacridine (therapeutic use)
• Female
• Humans
• Iodophors (therapeutic use)
• Male
• Middle Aged
• Wound Healing