[Advances in the study of A2B adenosine receptor antagonists].

Abstract

A2B adenosine receptor is involved in the control of mast cell degranulation, interleukin-8 synthesis and cell growth. A2B adenosine receptor antagonists may serve as novel drugs for asthma, Alzheimer' s disease, cystic fibrosis and type-II diabetes. Therefore, seeking for the highly selective A2B adenosine receptor antagonists has been one of great interest. The molecular basis, structure-activity relationship of selective A2B adenosine receptor antagonists and their interactions with A2B adenosine receptor were reviewed.

• Authors: Jing Wei, Wen-Quan Yu, Qing-Zhi Gao
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 43 Issue 3 Pg. 241-6 (Mar 2008) ISSN: 0513-4870 [Print] China
• PMID: 18630258 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adenosine A2 Receptor Antagonists
• Adenosine A3 Receptor Antagonists
• Anti-Asthmatic Agents
• Xanthines
• Adenosine-5'-(N-ethylcarboxamide)
• Adenosine

Topics

• Adenosine (pharmacology)
• Adenosine A2 Receptor Antagonists
• Adenosine A3 Receptor Antagonists
• Adenosine-5'-(N-ethylcarboxamide) (pharmacology, therapeutic use)
• Animals
• Anti-Asthmatic Agents (therapeutic use)
• Asthma (drug therapy)
• Humans
• Pulmonary Artery (drug effects)
• Structure-Activity Relationship
• Xanthines (pharmacology)