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[Antley-Bixler syndrome or POR deficiency?].

Abstract
Antley-Bixler syndrome (ABS) is a rare congenital disorder characterized by numerous craniofacial, skeletal and, in some cases, urogenital abnormalities resulting from disordered steroidogenesis. Known genetic causes in sporadic cases of ABS include dominant mutations in the fibroblast growth factor 2 receptor gene (FGFR2). Recent research shows surprisingly that symptoms of Antley-Bixler syndrome, combined with disordered steroidogenesis and urogenital anomalies, are caused by mutations in the POR gene that encodes NADPH-cytochrome P450 oxidoreductase (CYPOR). CYPOR is a four domain-containing monomeric flavoprotein that contains two flavins, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), a binding site for NADPH, and the N-terminal sequence of 25 amino acids which determines the microsomal localization of the protein. CYPOR is the electron donor to microsomally localized cytochromes P450 that participate in xenobiotic metabolism and steroidogenesis. Mutations in the POR gene lead to apparent diminished activity of some P450 enzymes. Association of CYPOR with ABS discloses new facts about this disease and recent research shows that patients with ABS-like skeletal anomalies, but with mutations in the POR gene and disordered steroidogenesis, represent a new disorder called POR deficiency.
AuthorsM Tomková, C C Marohnic, A Baxová, P Martásek
JournalCasopis lekaru ceskych (Cas Lek Cesk) Vol. 147 Issue 5 Pg. 261-5 ( 2008) ISSN: 0008-7335 [Print] Czech Republic
Vernacular TitleAntley-BixlerĊŻv syndrom nebo POR deficience?
PMID18630181 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • NADPH-Ferrihemoprotein Reductase
  • Receptor, Fibroblast Growth Factor, Type 2
Topics
  • Abnormalities, Multiple (diagnosis)
  • Humans
  • Mutation
  • NADPH-Ferrihemoprotein Reductase (deficiency, genetics)
  • Receptor, Fibroblast Growth Factor, Type 2 (genetics)
  • Syndrome

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