Abstract | BACKGROUND: OBJECTIVES: In this study we aimed to evaluate effects of in utero exposure to the antiandrogenic EDC vinclozolin, during the period of male reproductive tract development, on neonatal, prepubertal, and postpubertal prostate gland function of male offspring. METHODS: Fetal rats were exposed to vinclozolin (100 mg/kg body weight) or vehicle control (2.5 mL/kg body weight) in utero from gestational day 14 (GD14) to GD19 via oral administration to pregnant dams. Tissue analysis was carried out when male offspring were 0, 4, or 8 weeks of age. RESULTS: CONCLUSIONS: These data are the first to unequivocally implicate EDCs as a causative factor and fill an important knowledge gap on the etiology of prostatitis.
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Authors | Prue A Cowin, Paul Foster, John Pedersen, Shelley Hedwards, Stephen J McPherson, Gail P Risbridger |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 116
Issue 7
Pg. 923-9
(Jul 2008)
ISSN: 0091-6765 [Print] United States |
PMID | 18629315
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Androgen Antagonists
- Interleukin-8
- NF-kappa B
- Oxazoles
- Transforming Growth Factor beta1
- vinclozolin
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Topics |
- Active Transport, Cell Nucleus
- Androgen Antagonists
(toxicity)
- Animals
- Cell Nucleus
(metabolism)
- Epithelium
(growth & development, pathology)
- Female
- Humans
- Interleukin-8
(metabolism)
- Male
- Maternal-Fetal Exchange
- Morphogenesis
- NF-kappa B
(metabolism)
- Oxazoles
(toxicity)
- Pregnancy
- Prenatal Exposure Delayed Effects
- Prostate
(growth & development, pathology)
- Prostatitis
(chemically induced, metabolism, pathology)
- Rats
- Rats, Sprague-Dawley
- Sexual Maturation
- Transforming Growth Factor beta1
(metabolism)
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