Abstract | PURPOSE: DESIGN: Noncomparative case series. PARTICIPANTS: METHODS: Fine needle aspiration biopsy was used at the time of plaque radiotherapy to sample tumor cells for genetic testing. MAIN OUTCOME MEASURES:
Tumor thickness regression based on chromosome 3 status. RESULTS: At the time of plaque radiotherapy, the median tumor thickness was 4.0 mm for melanomas with chromosome 3 monosomy and 3.5 mm for those with disomy 3. The median tumor thickness (% original thickness) at 4, 8, 12, 15, and 18 months after radiotherapy for melanoma with monosomy 3 was 77%, 67%, 58%, 55%, and 50% and for those with disomy 3 was 82%, 70%, 69%, 67%, and 61%. The median monthly regression rate was 3.1% for tumors with monosomy 3 and 2.7% for those with disomy 3. The overall regression and monthly rate of regression was statistically greater at 12 months (P < 0.001) and 15 months (P = 0.003) for melanomas with monosomy 3 compared with disomy 3. CONCLUSIONS:
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Authors | Carol L Shields, Carlos Bianciotto, Danielle Rudich, Miguel A Materin, Arupa Ganguly, Jerry A Shields |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 28
Issue 9
Pg. 1289-95
(Oct 2008)
ISSN: 1539-2864 [Electronic] United States |
PMID | 18628721
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biopsy, Fine-Needle
- Brachytherapy
- Chromosome Aberrations
- Chromosomes, Human, Pair 3
- Humans
- Hyperthermia, Induced
- Melanoma
(genetics, pathology, therapy)
- Middle Aged
- Monosomy
- Time Factors
- Treatment Outcome
- Uveal Neoplasms
(genetics, pathology, therapy)
- Young Adult
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