Abstract | OBJECTIVES:
Systemic lupus erythematosus (SLE) is typically associated with hypergammaglobulinaemia but has been described in the setting of hypogammaglobulinaemia as well. The purpose of this article is to describe various cases of SLE and hypogammaglobulinaemia, review the literature and present management strategies for hypogammaglobulinaemia in SLE. METHODS: We describe five patients with SLE and antibody deficiency, and review the literature exploring the relationship between the two. RESULTS: CONCLUSION: Measurement of immunoglobulin levels is useful in SLE to identify coexisting antibody deficiency and the later development of hypogammaglobulinaemia. This allows monitoring and appropriate treatment to be instituted.
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Authors | P F K Yong, L Aslam, M Y Karim, M A Khamashta |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 47
Issue 9
Pg. 1400-5
(Sep 2008)
ISSN: 1462-0332 [Electronic] England |
PMID | 18625660
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Immunoglobulin M
- Immunoglobulins
- Immunoglobulins, Intravenous
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Topics |
- Adult
- Agammaglobulinemia
(etiology, therapy)
- Aged
- Anti-Bacterial Agents
(therapeutic use)
- Common Variable Immunodeficiency
(etiology)
- Female
- Humans
- IgA Deficiency
(etiology)
- Immunoglobulin M
(deficiency)
- Immunoglobulins
(blood)
- Immunoglobulins, Intravenous
(therapeutic use)
- Lupus Erythematosus, Systemic
(complications)
- Lupus Nephritis
(complications)
- Male
- Nephrotic Syndrome
(immunology)
- Opportunistic Infections
(complications, drug therapy)
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