Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.

Abstract

Aggressive fibromatosis (desmoid tumor) is a very rare neoplasm arising from the musculoaponeurotic structures. It is characterized by locally aggressive growth, and a tendency to relapse but not to metastasize. We report on a young woman with a large desmoid tumor of the left foot. Multiple operations and radiotherapy had resulted in local recurrences. Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease.

• Authors: Gabriele Stengel, Dieter Metze, Bernd Dörflinger, Thomas A Luger, Markus Böhm
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 59 Issue 2 Suppl 1 Pg. S7-9 (Aug 2008) ISSN: 1097-6787 [Electronic] United States
• PMID: 18625396 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Polyethylene Glycols
• peginterferon alfa-2b

Topics

• Adult
• Antineoplastic Agents (administration & dosage)
• Biopsy
• Female
• Fibromatosis, Aggressive (drug therapy, pathology)
• Foot
• Humans
• Interferon alpha-2
• Interferon-alpha (administration & dosage)
• Neoplasm Recurrence, Local (drug therapy)
• Polyethylene Glycols
• Recombinant Proteins
• Severity of Illness Index
• Soft Tissue Neoplasms (drug therapy, pathology)