Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells.

Abstract

This study is the first to investigate Calebin-A, a natural compound present in Curcuma longa, which inhibits cell growth and induce apoptosis in SGC7901/VINCRISTINE cells, a multidrug resistant (MDR) human gastric adenocarcinoma cell line. Our data suggest the drug efflux function of P-glycoprotein was inhibited by Calebin-A treatment, while the expression level of P-glycoprotein was not affected. Additionally, co-treatment of Calebin-A and vincristine resulted in a remarkable reduction in S phase and G2/M phase arrest in SGC7901/VINCRISTINE cells. Calebin-A was also found to modulate the activities of mitogen-activated protein kinase (MAPK) family members, which includes decreased c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and increased protein kinase of 38 kDa (p38) activity. These results suggest that Calebin-A might be an effective compound for the treatment of human gastric and other MDR cancers.

• Authors: Yan Li, Shaoqing Li, Yueheng Han, Junye Liu, Jian Zhang, Fuyang Li, Yun Wang, Xinping Liu, Libo Yao
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 591 Issue 1-3 Pg. 252-8 (Sep 04 2008) ISSN: 0014-2999 [Print] Netherlands
• PMID: 18619958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 1
• Antineoplastic Agents, Phytogenic
• Cinnamates
• Monoterpenes
• calebin-A
• Vincristine
• Mitogen-Activated Protein Kinases

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 1 (drug effects, metabolism)
• Adenocarcinoma (drug therapy, pathology)
• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Cell Cycle (drug effects)
• Cell Line, Tumor
• Cinnamates (pharmacology)
• Curcuma (chemistry)
• Drug Resistance, Multiple
• Drug Resistance, Neoplasm
• Drug Therapy, Combination
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Mitogen-Activated Protein Kinases (drug effects, metabolism)
• Monoterpenes (pharmacology)
• Stomach Neoplasms (drug therapy, pathology)
• Vincristine (pharmacology)