[Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat].

Abstract

OBJECTIVE:

To study the effect of SSd on lipid peroxidation during experimental hepatic fibrosis progression.

METHOD:

The experimental models of hepatic fibrosis were induced by intraperitoneal injection of dimethylnitrosamine (DMN) on rats. SSd was administered by intraperitoneal injection for 4 weeks. Serum was analyzed for alanine and aspartate aminotransferase (ALT and AST), hyaluronic acid (HA), laminin (LN), collagen IV (IV-C), malonaldehyde (MDA) and superoxide dismutase (SOD) activities. Liver samples were measured for MDA contents and SOD activities in normal group, model group and SSd group.

RESULT:

SSd significantly decreased ALT and AST activities and lowered HA, LN and IV-C contents. It enhanced SOD activities in liver, while reduced MDA contents both in serum and liver.

CONCLUSION:

SSd has obvious effects of protecting hepatocytes and resisting hepatic fibrosis, and the mechanism may be associated with its anti-lipid peroxidation effect.

• Authors: Yan He, Zhi-Feng Hu, Ping Li, Cheng Xiao, Yu-Wu Chen, Ke-Ming Li, Jing-Zhen Guo, Lin Pan, Jia-Peng Xiong
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 33 Issue 8 Pg. 915-9 (Apr 2008) ISSN: 1001-5302 [Print] China
• PMID: 18619352 (Publication Type: Journal Article)

Chemical References

• Collagen Type IV
• Laminin
• Saponins
• Malondialdehyde
• Oleanolic Acid
• Hyaluronic Acid
• Superoxide Dismutase
• Aspartate Aminotransferases
• Dimethylnitrosamine
• saikosaponin D

Topics

• Animals
• Aspartate Aminotransferases (blood)
• Collagen Type IV (blood)
• Dimethylnitrosamine (adverse effects)
• Hyaluronic Acid (blood)
• Laminin (blood)
• Lipid Peroxidation (drug effects)
• Liver Cirrhosis (blood, chemically induced, drug therapy, metabolism)
• Malondialdehyde (blood)
• Oleanolic Acid (analogs & derivatives, pharmacology, therapeutic use)
• Rats
• Saponins (pharmacology, therapeutic use)
• Superoxide Dismutase (blood)