| Abstract | BACKGROUND/AIM: Obesity has multiple causes and is determined by the interaction between genetic and environmental factors. A genetic factor is a (Trp64Arg) missense mutation in the beta 3-adrenergic receptor. The aim of our study was to investigate the influence of Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on weight, adipocytokines, insulin resistance, and fat distribution in obese patients. METHODS: A population of 217 nondiabetic obese Caucasian outpatients was analyzed. Indirect calorimetry and tetrapolar bioimpedance results, blood pressure, nutritional intake with 3-day food records, and biochemical parameters were evaluated. The genotype of beta 3-adrenergic receptor gene polymorphism (Trp64Arg) was studied. RESULTS: The mean age of the patients was 44.3 +/- 16.4 years, and the mean body mass index was 35.2 +/- 5.2. One hundred and eighty-six patients (52 males and 134 females; 85.8%) had the genotype Trp64/Trp64 (wild-type group), and 31 patients (11 males and 20 females; 14.2%) had the genotype Trp64/Arg64 (mutant group). In the mutant group, body mass index, weight, fat mass, waist-to-hip ratio, waist circumference, and C-reactive protein levels were higher than in the wild-type group. The adipocytokine levels were similar in both groups. CONCLUSION: The patients of the mutant group (Trp64/Arg64) had higher body mass index, weight, waist circumference, fat mass, waist-to-hip ratio, and C-reactive protein values than those of the wild-type group. |
| Authors | D A de Luis, R Aller, O Izaola, M Gonzalez Sagrado, R Conde
(Affiliation: Institute of Endocrinology and Nutrition, Hospital Rio Hortega, University of Valladolid, 12D056/0013 Valladolid, Spain. dadluis at yahoo.es)
|
| Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 52
Issue 4
Pg. 267-71
( 2008)
ISSN: 1421-9697 Switzerland |
| PMID | 18617734
(Publication Type: Journal Article)
|
| Copyright | 2008 S. Karger AG, Basel. |
| Chemical References |
- Adipokines
- Adiponectin
- Blood Glucose
- Leptin
- Receptors, Adrenergic, beta-3
- Resistin
- Cholesterol
- C-Reactive Protein
|
| Topics |
- Adipokines
(blood)
- Adiponectin
(blood)
- Adult
- Blood Glucose
(metabolism)
- Body Fat Distribution
- C-Reactive Protein
(analysis)
- Calorimetry, Indirect
- Cholesterol
(blood)
- Diet
- Female
- Genotype
- Humans
- Insulin Resistance
(genetics)
- Leptin
(blood)
- Male
- Mutation, Missense
- Obesity
(blood, genetics)
- Polymorphism, Genetic
- Prospective Studies
- Receptors, Adrenergic, beta-3
(genetics)
- Resistin
(blood)
|
