Abstract |
Five limonoids isolated from the seeds of Chisocheton siamensis were tested for their antimalarial activity against Plasmodium falciparum, antimycobacterial activity against Mycobacterium tuberculosis and cytotoxic activity against NCI-H187 (human small cell lung cancer), KB (oral human epidermal carcinoma) and MCF-7 ( breast cancer) cancer cell lines. All limonoids (1-5) showed inhibitory effect against Plasmodium falciparum with IC(50) values ranging from 2.06 to 6.31 microg/ml. Only azadiradione (2) exhibited strong inhibitory effect against Mycobacterium tuberculosis with the MIC of 6.25 microg/ml. Compounds 1-4 also showed cytotoxic activity against NCI-H187, KB and MCF-7 cancer cell lines and dysobinine (1) had the highest activity with IC(50) of 1.67, 3.17 and 2.15 microg/ml, respectively.
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Authors | W Maneerat, S Laphookhieo, S Koysomboon, K Chantrapromma |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 15
Issue 12
Pg. 1130-4
(Dec 2008)
ISSN: 1618-095X [Electronic] Germany |
PMID | 18617378
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Antimalarials
- Antineoplastic Agents
- Limonins
- Plant Extracts
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Topics |
- Animals
- Anti-Bacterial Agents
(isolation & purification, pharmacology)
- Antimalarials
(isolation & purification, pharmacology)
- Antineoplastic Agents
(isolation & purification, pharmacology)
- Cell Line, Tumor
- Humans
- Limonins
(isolation & purification, pharmacology)
- Meliaceae
(chemistry)
- Mycobacterium tuberculosis
(drug effects)
- Plant Extracts
(chemistry)
- Plasmodium falciparum
(drug effects)
- Seeds
(chemistry)
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