Topical 10% zinc sulfate solution for treatment of melasma.

Abstract

BACKGROUND:

Multiple modalities have been used in the treatment of melasma, such as bleaching agents, chemical peels, and antioxidants. Topical zinc sulfate has peeling and antioxidant effects.

OBJECTIVE:

The objective was to evaluate the efficacy and safety of topical 10% zinc sulfate solution in the treatment of melasma.

PATIENTS & METHODS:

This study was conducted at the Department of Dermatology & Venereology, Baghdad Teaching Hospital. Twenty-eight patients with melasma were treated with 10% zinc sulfate solution. Every patient was instructed to apply the formula twice daily and to be seen every 2 weeks for 2 months. The severity of melasma was assessed before, during, and after treatment with the melasma area and severity index (MASI). All patients were instructed to apply a broad-spectrum sunscreen with SPF>30 before sun exposure during treatment and for the 3-month follow-up period.

RESULTS:

Fourteen patients were treated with 10% zinc sulfate solution. The mean MASI score before treatment was 9.45, which changed to 4.70 after therapy. This corresponds to a percentage improvement of 49.78% and was statistically significant (p<.0005). No side effects were reported apart from a mild stinging sensation reported in a few patients. Most patients maintained improvement 3 months after cessation of therapy.

CONCLUSION:

Topical 10% zinc sulfate solution is a new effective, safe, and noncostly formulation in the treatment of melasma.

• Authors: Khalifa E Sharquie, Sabeeh A Al-Mashhadani, Hussam A Salman
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 34 Issue 10 Pg. 1346-9 (Oct 2008) ISSN: 1524-4725 [Electronic] United States
• PMID: 18616534 (Publication Type: Journal Article)

Chemical References

• Dermatologic Agents
• Zinc Sulfate

Topics

• Administration, Topical
• Adolescent
• Adult
• Dermatologic Agents (administration & dosage)
• Female
• Humans
• Male
• Melanosis (drug therapy)
• Middle Aged
• Treatment Outcome
• Young Adult
• Zinc Sulfate (administration & dosage)