Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion.

Abstract

BACKGROUND:

Amine oxidases are ubiquitous enzymes involved in the metabolism of biogenic amines. Copper amine oxidases catalyze the oxidative deamination of primary amine groups of several biogenic amines, such as putrescine, cadaverine and histamine.

OBJECTIVE:

In the present review the effects of a plant amine oxidase (histaminase, EC1.4.3.6), purified from pea seedlings, in the prevention of splanchnic postischemic reperfusion damage are reported.

CONCLUSION:

Various studies have clearly indicated that the use of histaminase will offer a good perspective for a novel therapeutic approach in the medical treatment of intestinal ischemia.

• Authors: Salvatore Cuzzocrea, Emanuela Masini
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 17 Issue 8 Pg. 1151-60 (Aug 2008) ISSN: 1744-7658 [Electronic] England
• PMID: 18616412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Drugs, Investigational
• Reactive Oxygen Species
• Histamine
• Amine Oxidase (Copper-Containing)

Topics

• Amine Oxidase (Copper-Containing) (isolation & purification, pharmacology, therapeutic use)
• Animals
• Arterial Occlusive Diseases (drug therapy, metabolism)
• Drugs, Investigational (isolation & purification, pharmacology, therapeutic use)
• Histamine (metabolism)
• Humans
• Peas (enzymology)
• Reactive Oxygen Species (metabolism)
• Reperfusion Injury (drug therapy, metabolism)
• Seeds (enzymology)
• Splanchnic Circulation