Multimodal therapy for chronic tinnitus.

Abstract	From 2001 to 2006, we performed a retrospective study of patients suffering from chronic unilateral or bilateral tinnitus that was previously ineffectively treated by oral drugs [betahistine (Betaserc), extract of Ginkgo biloba (EGb 761), tanakan (Tebokan), and cinnarizine-dimenhydrinate (Arlevert), singly or in combination]. We divided 150 tinnitus patients (80 men, 70 women) into seven treatment groups. Treatments consisted of application of intravenous pentoxifylline, lidocaine, or vinpocetine (Cavinton) and combination of these agents with physiotherapy and soft laser. Mean duration (+/- standard deviation) of tinnitus in these patients was 7.4 +/- 6.0 years; their mean age was 55.6 +/- 12.5 years. The aim of our study was to compare treatment modalities and define their effectiveness for tinnitus relief. The most effective treatment was defined as a combination of Cavinton and physiotherapy. We evaluated pure lidocaine infusion therapy as ineffective. None of the treatment modalities had an objective correlate of improvement, though improvement was reported by a visual analog scale.
Authors	Ales Hahn, Lenka Radkova, Gabriela Achiemere, Vladislav Klement, Dario Alpini, Jaroslav Strouhal
Journal	The international tinnitus journal (Int Tinnitus J) Vol. 14 Issue 1 Pg. 69-72 ( 2008) ISSN: 0946-5448 [Print] United States
PMID	18616089 (Publication Type: Comparative Study, Journal Article)
Chemical References	Drug Combinations Plant Extracts Vinca Alkaloids cinnarizine, dimenhydrinate drug combination Ginkgo biloba extract Cinnarizine vinpocetine Lidocaine Dimenhydrinate Pentoxifylline Betahistine
Topics	Adult Aged Betahistine (therapeutic use) Chronic Disease Cinnarizine (therapeutic use) Combined Modality Therapy Dimenhydrinate (therapeutic use) Drug Combinations Drug Therapy, Combination Female Ginkgo biloba Humans Lidocaine (therapeutic use) Low-Level Light Therapy Male Middle Aged Pentoxifylline (therapeutic use) Physical Therapy Modalities Plant Extracts (therapeutic use) Retrospective Studies Tinnitus (rehabilitation) Vinca Alkaloids (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!