Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice.

Abstract

Dopamine is important in the pathogenesis of hypertension because of abnormalities in receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified into D(1)-like (D(1), D(5)) and D(2)-like (D(2), D(3), D(4)) subtypes, all of which are expressed in the kidney. Mice deficient in specific dopamine receptors have been generated to provide holistic assessment on the varying physiological roles of each receptor subtype. This review examines recent studies on these mutant mouse models and evaluates the impact of individual dopamine receptor subtypes on blood pressure regulation.

• Authors: Xiaoyan Wang, Van Anthony M Villar, Ines Armando, Gilbert M Eisner, Robin A Felder, Pedro A Jose
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 23 Issue 12 Pg. 2131-46 (Dec 2008) ISSN: 0931-041X [Print] Germany
• PMID: 18615257 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Receptors, Dopamine
• Receptors, G-Protein-Coupled
• Sodium
• Dopamine

Topics

• Animals
• Disease Models, Animal
• Dopamine (metabolism)
• Hypertension (genetics, metabolism)
• Kidney (metabolism)
• Mice
• Mice, Knockout
• Receptors, Dopamine (genetics, metabolism)
• Receptors, G-Protein-Coupled (genetics, metabolism)
• Sodium (metabolism)