Abstract |
Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease mainly stemming from a genetic predisposition that leads to hypersensitivity to environmental factors and a common involvement of Staphylococcus aureus (SA) colonization. The aim of this work was to propose a new non-invasive approach to enumerate the genes coding for the toxins of SA in atopic skin samples. In parallel, the study aimed to evaluate the change in AD through 3 markers of the inflammatory response: IL-8, IL-1RA/IL-1alpha and IL-18. These methods were tested on 31 patients with AD, and finally on a group of 19 subjects for whom clinical improvement had been reported after various treatments. The study revealed the presence of a large number of genes encoding toxins in atopic samples, indicating a high rate of SA colonization, and also an increase in the level of all cytokine markers in atopic skin compared to the skin of healthy subjects. Finally, we found a positive correlation between increases in the SCORAD (Scoring Atopic Dermatitis Index) value after treatment and the corresponding evolution of the SA density. These methods provide a means to clinically evaluate the course of AD, and may help in the development of potential treatments.
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Authors | C Casas, H Ginisty, S Alvarez-Georges, C Viodé, O Lejeune, C Rouvrais, A M Schmitt, D Redoulès |
Journal | Skin pharmacology and physiology
(Skin Pharmacol Physiol)
Vol. 21
Issue 5
Pg. 260-8
( 2008)
ISSN: 1660-5535 [Electronic] Switzerland |
PMID | 18612217
(Publication Type: Journal Article)
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Copyright | Copyright 2008 S. Karger AG, Basel. |
Chemical References |
- Bacterial Toxins
- DNA, Bacterial
- Interleukins
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Topics |
- Bacterial Toxins
(genetics, isolation & purification)
- Case-Control Studies
- Child
- Child, Preschool
- DNA, Bacterial
(isolation & purification)
- Dermatitis, Atopic
(genetics, microbiology)
- Genetic Predisposition to Disease
- Genotype
- Humans
- Infant
- Inflammation
(genetics, microbiology)
- Interleukins
(metabolism)
- Oligonucleotide Array Sequence Analysis
(methods)
- Polymerase Chain Reaction
(methods)
- Severity of Illness Index
- Staphylococcal Skin Infections
(genetics, microbiology)
- Staphylococcus aureus
(genetics, isolation & purification)
- Treatment Outcome
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