Abstract | BACKGROUND: OBJECTIVES: The objective of the study was to analyze expression of IGF-II and its receptor (IGF-IR) in pediatric and adult adrenocortical tumors and the effects of a selective IGF-IR kinase inhibitor (NVP-AEW541) on adrenocortical tumor cells. PATIENTS: METHODS: Gene expression was determined by quantitative real-time PCR. Cell proliferation and apoptosis were analyzed in NCI H295 cells and a new cell line established from a pediatric adrenocortical adenoma. RESULTS: CONCLUSION:
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Authors | Madson Q Almeida, Maria Candida Barisson Villares Fragoso, Claudimara Ferini Pacicco Lotfi, Mariza Gerdulo Santos, Mirian Yumie Nishi, Marcia Helena Soares Costa, Antonio Marcondes Lerario, Carolina Canton Maciel, Gabriele Ebling Mattos, Alexander Augusto Lima Jorge, Berenice B Mendonca, Ana Claudia Latronico |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 93
Issue 9
Pg. 3524-31
(Sep 2008)
ISSN: 0021-972X [Print] United States |
PMID | 18611974
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptor, IGF Type 2
- Insulin-Like Growth Factor II
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Topics |
- Adenoma
(genetics, pathology)
- Adolescent
- Adrenal Cortex Neoplasms
(genetics, pathology)
- Adult
- Aged
- Carcinoma
(genetics, pathology)
- Child
- Child, Preschool
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Infant
- Insulin-Like Growth Factor II
(genetics, metabolism)
- Male
- Middle Aged
- Neoplasm Metastasis
- Receptor, IGF Type 2
(genetics, metabolism)
- Tumor Cells, Cultured
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