Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/metronidazole in elective colon and rectum surgery: a prospective and randomized quality control study in 422 patients.

Abstract

As previous work has shown, antibiotic prophylaxis is highly effective in lowering wound infection rates in colorectal surgery. In order to establish quality control, the authors investigated the effectiveness of three different prophylactic antibiotic regimes in 422 patients in a prospective and randomized trial. There were no significant differences between the three groups with regard to age, type of operation and risk factors like adipositas and diabetes. The wound infection rate according to the Centers for Disease Control criteria ranged from 7.0% to 9.5%. No significant difference was found between the three antibiotic regimes. It can be concluded, therefore, that under the conditions used in this study each of the three different types of antibiotics is of equal value, hence, the cheapest one can be used.

• Authors: J Menzel, J Bauer, E von Pritzbauer, I Klempa
• Journal: International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 6 Suppl Pg. S79-82 (Apr 1996) ISSN: 0924-8579 [Print] Netherlands
• PMID: 18611725 (Publication Type: Journal Article)