Chitotriosidase and soluble IL-2 receptor: comparison of two markers of sarcoidosis severity.

Abstract

BACKGROUND:

Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs.

AIMS AND METHODS:

The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers.

RESULTS:

Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease.

CONCLUSION:

Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression.

• Authors: Elena Bargagli, Nicola Bianchi, Maria Margollicci, Carmela Olivieri, Alice Luddi, Giuseppe Coviello, Salvatore Grosso, Paola Rottoli
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 68 Issue 6 Pg. 479-83 ( 2008) ISSN: 1502-7686 [Electronic] England
• PMID: 18609101 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers
• Receptors, Interleukin-2
• Hexosaminidases
• chitotriosidase

Topics

• Biomarkers (blood)
• Female
• Health
• Hexosaminidases (metabolism)
• Humans
• Male
• Middle Aged
• Receptors, Interleukin-2 (blood)
• Sarcoidosis (blood, enzymology, pathology)
• Smoking
• Solubility