Abstract | BACKGROUND:
Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs. AIMS AND METHODS: The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers. RESULTS:
Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease. CONCLUSION:
Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression.
|
Authors | Elena Bargagli, Nicola Bianchi, Maria Margollicci, Carmela Olivieri, Alice Luddi, Giuseppe Coviello, Salvatore Grosso, Paola Rottoli |
Journal | Scandinavian journal of clinical and laboratory investigation
(Scand J Clin Lab Invest)
Vol. 68
Issue 6
Pg. 479-83
( 2008)
ISSN: 1502-7686 [Electronic] England |
PMID | 18609101
(Publication Type: Comparative Study, Journal Article)
|
Chemical References |
- Biomarkers
- Receptors, Interleukin-2
- Hexosaminidases
- chitotriosidase
|
Topics |
- Biomarkers
(blood)
- Female
- Health
- Hexosaminidases
(metabolism)
- Humans
- Male
- Middle Aged
- Receptors, Interleukin-2
(blood)
- Sarcoidosis
(blood, enzymology, pathology)
- Smoking
- Solubility
|