Clinical efficacy of a petroleum-derived product (Larimsh) used as compassionate treatment in patients with terminal prostate cancer.

Treatment of a light fraction of petroleum treated by metallic catalysis results in a liquid mixture of low molecular weight compounds named LarimshTM (LR). Acute and chronic topical treatment of mice with LR (85 days with 0.1 to 1 mL/animal) indicated no signs of toxicity other than a non dose-dependent, reversible alopecia appearing by the 4th week of topical application. Alopecia completely reversed 2 weeks after treatment withdrawal. Acute oral LR (0.001 to 1 mL; the lowest doses diluted in corn oil as vehicle) gave an estimated LD50 of 21 g/kg (C.I. 95 %: 10.94-41.2 g/kg. LR density = 0.867 g/mL). The antineoplastic action of LR was observed using combined oral and topical treatments in mice; inoculated with a lymphoid leukemia cell line in ascitic phase (International Registry L5178Y); and in terminal patients with prostate cancer (TPCA)--who agreed to receive LR as a compassionate treatment. The survival time for mice was significantly increased when compared with non-treated inoculated mice (51 +/- 2 versus 38 +/- 2 days, p < 0.05, mean +/- SD, N = 6 per group). In 15 patients, LR treatment for 5.5 months (C.I. 95 %: 2.9 to 8.0 months) significantly increased the expected survival time diagnosed to TPCA by their treating physicians (C.I. 95 %: 2.2 to 5.4 versus 12.6 to 41.2 months, p < 0.05) which occurred concomitantly with a significant reduction of blood levels of total prostatic antigen (average 94.5%, range: 67.3 to 99.9%). A theoretical proposal is advanced as a likely explanation of LR actions.
AuthorsRafaín Rodríguez-Pérez, Maritza García-Montañez, Humberto Lemus-Balcazar, Marcos DeLaRosa Viejo, Jaime Grijalva-Monreal, Andrés E Castell-Rodríguez, María Dolores Ramírez-González
JournalProceedings of the Western Pharmacology Society (Proc West Pharmacol Soc) Vol. 50 Pg. 143-51 ( 2007) ISSN: 0083-8969 [Print] United States
PMID18605253 (Publication Type: Journal Article)
Chemical References
  • Petroleum
  • larimsh
  • Prostate-Specific Antigen
  • Animals
  • Bone and Bones (radionuclide imaging)
  • Cell Line, Tumor
  • Chromatography, Gas
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Middle Aged
  • Palliative Care
  • Petroleum (analysis)
  • Prostate-Specific Antigen (blood)
  • Prostatic Neoplasms (radionuclide imaging, therapy)
  • Quality Control
  • Survival Analysis

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