A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.

Abstract

BACKGROUND:

A 71-year-old woman was referred to a surgical oncology clinic after CT raised suspicion for a bladder neoplasm. She had previously undergone right hemicolectomy and received adjuvant chemotherapy for pT3N1MX cancer of the cecum. A retroperitoneal recurrence had been deemed unsuitable for surgical resection, and had instead been treated with chemoradiation therapy. Follow-up CT raised suspicion for a possible bladder neoplasm.

INVESTIGATIONS:

CT, physical examination, urinalysis, cystoscopy with biopsy, pathological analysis and immunohistochemical analysis.

DIAGNOSIS:

Adenocarcinoma of the cecum metastatic to the bladder.

MANAGEMENT:

The patient underwent open bladder resection with total excision of the neoplasm and was administered adjuvant chemotherapy consisting of irinotecan and cetuximab. Subsequent recurrences at the same site were treated with transurethral resection, while chemotherapy was still in progress. At 7 months' follow-up, the patient remained alive, with no evidence of further recurrence.

• Authors: Luciano Izzo, Dario Pietrasanta, Paolo Izzo, Maria Caputo, Pierfrancesco Di Cello, Paolo Meloni, Antonio Bolognese
• Journal: Nature clinical practice. Urology (Nat Clin Pract Urol) Vol. 5 Issue 7 Pg. 403-7 (Jul 2008) ISSN: 1743-4289 [Electronic] United States
• PMID: 18604226 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antimetabolites, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Organoplatinum Compounds
• Quinazolines
• Thiophenes
• Irinotecan
• raltitrexed
• Cetuximab
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Adenocarcinoma (diagnostic imaging, drug therapy, metabolism, pathology, surgery)
• Aged
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized
• Antimetabolites, Antineoplastic (therapeutic use)
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Camptothecin (analogs & derivatives, therapeutic use)
• Cecal Neoplasms (drug therapy, metabolism, pathology, surgery)
• Cetuximab
• Chemotherapy, Adjuvant
• Colectomy
• Female
• Fluorouracil (therapeutic use)
• Humans
• Immunohistochemistry
• Irinotecan
• Leucovorin (therapeutic use)
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (drug therapy, secondary, surgery)
• Organoplatinum Compounds (therapeutic use)
• Quinazolines (therapeutic use)
• Retroperitoneal Neoplasms (pathology, secondary)
• Sacrum (pathology)
• Thiophenes (therapeutic use)
• Tomography, X-Ray Computed
• Urinary Bladder Neoplasms (diagnostic imaging, drug therapy, metabolism, secondary, surgery)