HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clostridium perfringens enterotoxin in antibiotic-associated diarrhea.

Abstract
Clostridium perfringens type A is associated with 5-20% cases of antibiotic-associated diarrhea (AAD) even though Clostridium difficile is implicated in the most severe cases. Fecal specimens from one hundred hospitalized patients, who developed diarrhea regardless of antibiotic intake and who were negative for C. difficile toxin assay, were investigated for C. perfringens enterotoxin (CPE). Simultaneously, cultures were set up for other possible aetiological factors. Ten healthy controls were also similarly investigated. CPE was positive in 2/100 (2%) of the patients and the samples were also positive for the organism in culture. Other organisms isolated were non-toxigenic C. difficile (4%), staphylococci (6%), Candida (18%) and Klebsiella pneumoniae (1%). Stool samples from healthy controls grew mixed growth of no significance and CPE was negative in all of them. Detection of CPE is not part of routine laboratory investigation due to resource implication. Criteria for initiating investigations have to be therefore established by understanding the true burden of C. perfringens-associated AAD by further research.
AuthorsChetana Vaishnavi, Sukhminderjit Kaur
JournalIndian journal of pathology & microbiology (Indian J Pathol Microbiol) 2008 Apr-Jun Vol. 51 Issue 2 Pg. 198-9 ISSN: 0377-4929 [Print] India
PMID18603680 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Enterotoxins
  • enterotoxin, Clostridium
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents (adverse effects)
  • Child
  • Child, Preschool
  • Clostridium Infections (complications, drug therapy)
  • Clostridium perfringens (pathogenicity)
  • Diarrhea (chemically induced, etiology, microbiology)
  • Enterotoxins (analysis, toxicity)
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: