Abstract | OBJECTIVE: PATIENTS AND METHODS: RESULTS: Six weeks after BTA injections, the success rate was 75.8%, with improvement in 12.1% of cases and failure in 9.1% of cases. The mean number of self-catheterizations per 24 h was significantly decreased (6.37 versus 5.2, P=0.02), the maximum voiding volume was increased (321.68 ml versus 536.25 ml, P=0.002), the mean number of episodes of incontinence per 24 h was decreased (7.39 versus 0.03, P<0.0001), the proportion of patients with incontinence was decreased (66.66% versus 6.04%, P<0.0001), the mean maximum cystomanometric capacity was increased (286.75 ml versus 554.16 ml, P=0.002) and the mean maximum intravesical pressure was decreased (54.8 cm H(2)O versus 5.3 cm H(2)O, P<0.0001). After BTA injections, 87.8 % of patients no longer experienced uninhibited contractions. The median duration of clinical efficacy was 7.03 months. At 12 months, injections were still effective clinically in 21.2 % of patients. CONCLUSION: Intradetrusor BTA injections are an effective and well tolerated treatment for neurogenic overactive bladder. Their clinical efficacy persisted for more than 12 months in more than 20% of cases.
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Authors | Y Bentaleb, E Castel-Lacanal, F Sallusto, X De Boissezon, B Malavaud, P Marque, P Rischmann, X Gamé |
Journal | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
(Prog Urol)
Vol. 18
Issue 7
Pg. 449-55
(Jul 2008)
ISSN: 1166-7087 [Print] France |
Vernacular Title | Etude prospective des résultats cliniques et urodynamiques des injections intradétrusoriennes de toxine botulique dans le traitement de l'hyperactivité détrusorienne neurogène. |
PMID | 18602606
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adult
- Botulinum Toxins, Type A
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Injections, Intramuscular
- Male
- Middle Aged
- Neuromuscular Agents
(administration & dosage)
- Prospective Studies
- Time Factors
- Urinary Bladder, Neurogenic
(drug therapy)
- Urinary Bladder, Overactive
(drug therapy)
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