Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: We tested the hypothesis that SMGGT could inhibit cytotoxic effect of EV71. MATERIALS AND METHODS: Human foreskin fibroblast cell line was used for viral culture. Cytotoxicity was examined by XTT assay. RESULTS: SMGGT could inhibit cytopathy induced by EV71 when given before (p<0.0001), in association with (p<0.0001), or after viral infection (p<0.0001). SMGGT was effective (IC(50): 0.21 microg/ml) and safe (SI: more than 24,000). SMGGT could inhibit viral attachment (p<0.0001) and penetration (p<0.0001). EV71 infection could induce cellular interferon production (p<0.0001). However, SMGGT affected neither the virus-induced (p=0.9913), nor the constitutional interferon production (p>0.05). Therefore, SMGGT had direct anti-viral activity not mediated by interferon. CONCLUSIONS: SMGGT was effective on management of the disease induced by EV71 infection.
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Authors | Jung San Chang, Kuo Chih Wang, Lien Chai Chiang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 119
Issue 1
Pg. 104-8
(Sep 02 2008)
ISSN: 0378-8741 [Print] Ireland |
PMID | 18601992
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- Drugs, Chinese Herbal
- Interferon-beta
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Topics |
- Antiviral Agents
(administration & dosage, pharmacology, toxicity)
- Cell Line
- Drugs, Chinese Herbal
(administration & dosage, pharmacology, toxicity)
- Enterovirus A, Human
(drug effects)
- Fibroblasts
(drug effects, metabolism)
- Foreskin
- Humans
- Inhibitory Concentration 50
- Interferon-beta
(drug effects, metabolism)
- Male
- Toxicity Tests
- Virus Attachment
(drug effects)
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