Abstract |
Bisphosphonates is a class of chemical compounds finding extensive medical applications against bone disorders including osteoporosis, Pagets' disease, etc. Non-N-containing members include etidronate, clodronate and tiludronate, while N-containing bisphosphonates include active pharmaceutical compounds such as pamidronate, neridronate, olpadronate, alendronate, ibandronate, risedronate and zoledronate. The present study covers 20 years of analytical research on this group of compounds, focusing on bioanalytical and pharmaceutical QC applications. A wide range of analytical techniques is presented and critically discussed including among others liquid and gas phase separations, electrophoretic, electroanalytical, automated and enzymatic approaches.
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Authors | Constantinos K Zacharis, Paraskevas D Tzanavaras |
Journal | Journal of pharmaceutical and biomedical analysis
(J Pharm Biomed Anal)
Vol. 48
Issue 3
Pg. 483-96
(Nov 04 2008)
ISSN: 0731-7085 [Print] England |
PMID | 18599247
(Publication Type: Journal Article, Review)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Pharmaceutical Preparations
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Topics |
- Bone Density Conservation Agents
(analysis, chemistry)
- Chemistry Techniques, Analytical
(methods)
- Diphosphonates
(analysis, chemistry)
- Molecular Structure
- Pharmaceutical Preparations
(analysis, chemistry)
- Quality Control
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