Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: Positive GATA3 expression in hysterectomy specimens significantly correlated to high International Federation of Gynecology and Obstetrics stage, serous papillary/clear cell subtypes, high histologic grade, loss of PR expression, aneuploidy, high proliferation, pathologic p53 and p16 expression, and poor prognosis (P = .003). Loss of hormone receptors significantly correlated with aggressive phenotype and poor prognosis. Pathologic expression of GATA3/ ERalpha in combination added independent prognostic information. CONCLUSION: GATA3 expression is associated with an aggressive phenotype and adds independent prognostic information in addition to receptor status. Further studies of its value in tailored treatment protocols seem justified.
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Authors | Ingeborg B Engelsen, Ingunn M Stefansson, Lars A Akslen, Helga B Salvesen |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 199
Issue 5
Pg. 543.e1-7
(Nov 2008)
ISSN: 1097-6868 [Electronic] United States |
PMID | 18599012
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Estrogen Receptor alpha
- Estrogen Receptor beta
- GATA3 Transcription Factor
- GATA3 protein, human
- Receptors, Progesterone
- Tumor Suppressor Protein p53
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Topics |
- Aged
- Endometrial Neoplasms
(mortality, pathology)
- Estrogen Receptor alpha
(analysis)
- Estrogen Receptor beta
(analysis)
- Female
- Follow-Up Studies
- GATA3 Transcription Factor
(analysis)
- Genes, p16
- Humans
- Hysterectomy
- Immunohistochemistry
- Multivariate Analysis
- Prognosis
- Protein Array Analysis
- Receptors, Progesterone
(analysis)
- Tumor Suppressor Protein p53
(analysis)
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