Abstract | OBJECTIVES: Intranasal corticosteroids have been advanced as a nonsurgical therapeutic alternative for pediatric obstructive sleep apnea syndrome, particularly for patients with mild disease, and aims at reducing the size of hypertrophic adenotonsillar tissue. METHODS: Of 71 possible candidates, 62 children with polysomnographically diagnosed mild obstructive sleep apnea syndrome were recruited onto a double-blind, randomized, crossover trial of intranasal budesonide (32 microg per nostril at bedtime) or placebo for 6 weeks followed by an additional 6-week treatment in the alternative treatment arm after allowing for a 2-week washout period. Polysomnographic assessment and radiographs for assessment of adenoid size were performed after completion of each phase. RESULTS: There were significant improvements in both polysomnographic measures (sleep latency, slow-wave sleep, and rapid-eye-movement sleep), in the magnitude of respiratory disturbance ( apnea/hypopnea index, nadir pulse oxygen saturation), and in adenoid size among the 48 children who completed the treatment phase compared with 32 children who received placebo in their initial arm, with normalization of sleep measures in 54.1% of the treated children. Furthermore, discontinuation of treatment for 8 weeks for 25 children revealed a sustained duration of the initial treatment effect. CONCLUSIONS:
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Authors | Leila Kheirandish-Gozal, David Gozal |
Journal | Pediatrics
(Pediatrics)
Vol. 122
Issue 1
Pg. e149-55
(Jul 2008)
ISSN: 1098-4275 [Electronic] United States |
PMID | 18595959
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Budesonide
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Topics |
- Adenoids
(pathology)
- Administration, Intranasal
- Budesonide
(administration & dosage)
- Child
- Child, Preschool
- Cross-Over Studies
- Double-Blind Method
- Female
- Glucocorticoids
(administration & dosage)
- Humans
- Hypertrophy
- Infant
- Male
- Polysomnography
- Sleep Apnea, Obstructive
(drug therapy)
- Treatment Outcome
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