Abstract | OBJECTIVE: The purpose of this study was to identify risk factors for poor clinical outcome after surgical resection of small lung adenocarcinoma. MATERIALS AND METHODS: RESULTS: Based on the percentage of non-BAC component, 127 patients were classified as follows: 26 in group I, BAC, 46 in group II mixed subtype with >or= 50% BAC, 18 in group III, mixed subtype with under 50% BAC, and 37 in group IV, mixed subtype with all non-BAC components or a pure pattern of one of the non-BAC components. Groups I and II were considered to be a "low non-BAC component type" and groups III and IV were considered to be a "high non-BAC component type." EGFR mutations in exon19 and exon21 were observed in 64 patients (50.4%). In terms of recurrence, the high non-BAC component type was the only independent factor for recurrence (p = 0.029). Regarding survival, the high age (p = 0.028) and high non-BAC component type (p = 0.046) were independent risk factors for poor overall survival. They were also independent risk factors for poor disease-free survival (p = 0.025 and p = 0.027, respectively). CONCLUSION: The high non-BAC component but not EGFR mutation status, is an independent risk factor for both recurrence and poor prognosis in patients with stage IA lung adenocarcinoma <or=20 mm.
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Authors | Naruyuki Kobayashi, Shinichi Toyooka, Kouichi Ichimura, Junichi Soh, Hiromasa Yamamoto, Keitaro Matsuo, Hiroki Otani, Masaru Jida, Takafumi Kubo, Kazunori Tsukuda, Katsuyuki Kiura, Yoshifumi Sano, Hiroshi Date |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 3
Issue 7
Pg. 704-10
(Jul 2008)
ISSN: 1556-1380 [Electronic] United States |
PMID | 18594314
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adenocarcinoma
(genetics, mortality, pathology, secondary)
- Adenocarcinoma, Bronchiolo-Alveolar
(pathology)
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(genetics, mortality, pathology, secondary)
- Female
- Genes, erbB-1
(genetics)
- Humans
- Lung Neoplasms
(genetics, pathology)
- Male
- Middle Aged
- Mutation
- Neoplasm Recurrence, Local
- Prognosis
- Risk Factors
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