Serum-soluble interleukin-2 receptor (sIL-2R) is an extremely strong prognostic factor for patients with peripheral T-cell lymphoma, unspecified (PTCL-U).

Abstract

PURPOSE:

The aim of this study was to assess the prognostic factors of peripheral T-cell lymphoma, unspecified (PTCL-U).

PATIENTS AND METHODS:

We retrospectively analyzed 30 cases fulfilling the criteria of PTCL-U defined by the World Health Organization classification. The patients were treated with 6-8 cycles of a CHOP or THP (pirarubicin)-COP regimen.

RESULTS:

A high serum sIL-2R level (> or =2,000 U/ml) at onset was associated with a low complete remission rate. Patients with high sIL-2R had significantly lower survival rates (5 year, 15.1%) than those with low sIL-2R (<2,000 U/ml) (100%) (P < 0.005). Factors associated with worse overall survival in a univariate analysis were high sIL-2R (P < 0.005), high age (>60 years) (P < 0.05), poor performance status (P < 0.01) and poor international prognostic index (P < 0.05). No correlation was observed between sIL-2R and other markers. Multivariate analysis showed that only sIL-2R was a prognostic factor for overall survival (P < 0.01).

CONCLUSION:

The results suggest that a high serum sIL-2R level predicts a poor prognosis in PTCL-U.

• Authors: Jun-ichi Kitagawa, Takeshi Hara, Hisashi Tsurumi, Naoe Goto, Nobuhiro Kanemura, Takeshi Yoshikawa, Senji Kasahara, Toshiki Yamada, Michio Sawada, Takeshi Takahashi, Masahito Shimizu, Tsuyoshi Takami, Hisataka Moriwaki
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 135 Issue 1 Pg. 53-9 (Jan 2009) ISSN: 0171-5216 [Print] Germany
• PMID: 18592269 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Receptors, Interleukin-2

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor
• Female
• Humans
• Lymphoma, T-Cell, Peripheral (blood, drug therapy)
• Male
• Middle Aged
• Prognosis
• Receptors, Interleukin-2 (blood)
• Remission Induction
• Retrospective Studies
• Risk Factors
• Survival Rate
• Treatment Outcome
• Young Adult