Acute dystonia in a young schizophrenic patient associated with ingestion of a cloperastine containing cough syrup.

Abstract

Acute dystonic reactions are usually observed after exposure to drugs with antidopaminergic actions. We report on one patient with acute dystonia associated with ingestion of a cloperastine containing syrup, who suffered from schizophrenia but had been neuroleptic-free for 6months. Cloperastine has antihistaminic properties. We suggest that antihistaminic agents may induce acute dystonia by altering the balance between dopamine and acetylcholine in the striatum.

• Authors: G Linazasoro, M T Garmendia, X Lizaso
• Journal: Parkinsonism & related disorders (Parkinsonism Relat Disord) Vol. 6 Issue 1 Pg. 57-8 (Jan 2000) ISSN: 1353-8020 [Print] England
• PMID: 18591150 (Publication Type: Journal Article)