Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus.

Abstract

Deep brain stimulation is now accepted as a safe and efficient treatment for movement disorders including selected types of dystonia and dyskinesia. Very little, however, is known about its effect on other movement disorders, particularly for "choreic" movements. Huntington disease is a fatal autosomal-dominant neurodegenerative disorder characterized by movement disorders, progressive cognitive impairment, and psychiatric symptoms. Bilateral chronic stimulation of the internal globus pallidus was performed to control choreic movements in a 60-year-old man with a 10-year history of Huntington disease. Chronic deep brain stimulation resulted in remarkable improvement of choreic movements. Postoperative improvement was sustained after 4 years of follow-up with a marked improvement in daily quality of life.

• Authors: Brigitte Biolsi, Laura Cif, Hassan El Fertit, Santiago Gil Robles, Philippe Coubes
• Journal: Journal of neurosurgery (J Neurosurg) Vol. 109 Issue 1 Pg. 130-2 (Jul 2008) ISSN: 0022-3085 [Print] United States
• PMID: 18590443 (Publication Type: Case Reports, Journal Article)

Topics

• Deep Brain Stimulation
• Follow-Up Studies
• Globus Pallidus
• Humans
• Huntington Disease (pathology, physiopathology, therapy)
• Male
• Middle Aged
• Time Factors
• Treatment Outcome