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[Inducing differentiation effect on cells of serum from mice treated with Yang He decoction].

AbstractOBJECTIVE:
To observe inducing differention effect on cells of serum from mice treated with Yang He decoction (SMY).
METHODS:
The viability of B16 cells was tested by lactate dehydrogenase (LDH) release assay and sulforhordamine B (SRB) assay. The differentiation of 3T3-L1 preadipocyte, HL-60, K562 and B16 cells were assessed by microscopy and Oil red O staining, NBT reduction and phagocytosis, haemoglobin (Hb) content and melanin content, respectively.
RESULTS:
SMY could obviously inhibit growth of B16 cells without cytotoxicity, and promote Oil red O staining in 3T3-L1 preadipocyte, enhance the NBT reduction ability and the phagocytosis of horse radish peroxidase in HL-60 cells, increase Hb content in K562 cells, and decrease melanin content in B16 cells.
CONCLUSION:
SMY is able to induce functional differentiation and maturation of 3T3-L1 preadipocyte and tumor cells, which implies the major mechanism of Yang He decoction in antitumor.
AuthorsGang-jun Du, Hai-hong Lin, Song-qiang Xie
JournalZhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 31 Issue 1 Pg. 82-5 (Jan 2008) ISSN: 1001-4454 [Print] China
PMID18589756 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Culture Media
  • Drug Combinations
  • Drugs, Chinese Herbal
  • yanghe
Topics
  • 3T3-L1 Cells
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Cell Differentiation (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Culture Media (pharmacology)
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Drugs, Chinese Herbal (administration & dosage, chemistry, pharmacology)
  • HL-60 Cells
  • Humans
  • K562 Cells
  • Male
  • Mice
  • Phagocytosis (drug effects)
  • Plants, Medicinal (chemistry)
  • Serum

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