The response to chemotherapy of serum Mycobacterium leprae-specific antigen in multibacillary leprosy patients.

Abstract

We have examined the Mycobacterium leprae phenolic glycolipid-I (PG-I) antigen levels in the sera of 45 multibacillary leprosy patients commencing chemotherapy. The PG-I antigen levels correlated with the bacterial and morphological indices, but not with the serum IgM anti-PG-I antibody levels. Antigen levels were significantly higher in patients with diffuse skin infiltration, but did not vary significantly with other parameters reflecting the duration and extent of untreated disease. The PG-I antigen levels in 27 patients examined serially decreased consistently over the first year of multidrug therapy.

• Authors: P W Roche, W J Britton, K D Neupane, S S Failbus, S N Cho, W J Theuvenet
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 44 Issue 6 Pg. 702-8 (Jun 1991) ISSN: 0002-9637 [Print] United States
• PMID: 1858971 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Glycolipids
• Immunoglobulin M
• Leprostatic Agents
• phenolic glycolipid I, Mycobacterium leprae
• Dapsone
• Clofazimine
• Rifampin

Topics

• Antibodies, Bacterial (blood)
• Antigens, Bacterial (blood)
• Carbohydrate Sequence
• Clofazimine (therapeutic use)
• Dapsone (therapeutic use)
• Drug Therapy, Combination
• Glycolipids (blood)
• Humans
• Immunoglobulin M (analysis)
• Leprostatic Agents (therapeutic use)
• Leprosy (drug therapy, immunology, microbiology)
• Leprosy, Borderline (drug therapy, immunology, microbiology)
• Leprosy, Lepromatous (drug therapy, immunology, microbiology)
• Molecular Sequence Data
• Mycobacterium leprae (immunology, isolation & purification)
• Rifampin (therapeutic use)
• Skin (microbiology)
• Time Factors