In patients with Helicobacter pylori-positive
duodenal ulcer (DU), the organism must be eradicated to achieve rapid, stable healing. However, evidence is against much else that is commonly accepted. (1) Does H. pylori cause the
ulcer? Evidence against includes archaeopathology, geographical prevalence, temporal relationships and H. pylori-negative DU patients. DU can recur after eradication of H. pylori
infection, and DUs may remain healed after reduction of
acid secretion despite
persistent infection. The faster healing of
ulcers when H. pylori has been eradicated is due to the organism's interference with neoangiogenesis and the healing of wounded epithelial cells. (2) Does H. pylori
infection persist until pharmacologically eradicated? Studies based on current
infection show that H. pylori
infection is a labile state that can change in 3 months. High rates of gastric acid secretion result in spontaneous cure, whereas low rates permit
re-infection.
Hydrochloric acid, necessary for producing a DU, is strongly associated with the likelihood of an
ulcer. At the start, patients owe their
ulcer to gastric hypersecretion of
hydrochloric acid; approximately 60% may be H. pylori-negative. If
acid is suppressed, the less
acid milieu encourages invasion by H. pylori, especially if the strain is virulent.